Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection.

نویسندگان

  • Peter J Petersen
  • C Hal Jones
  • Aranapakam M Venkatesan
  • Patricia A Bradford
چکیده

The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (including extended-spectrum beta-lactamases), class C (AmpC), and class D beta-lactamase-expressing pathogens.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 53 4  شماره 

صفحات  -

تاریخ انتشار 2009